Alphafold Sovereign MCP
未认领BioMed MCP over AlphaFold DB + 8 public sources, with SQLite knowledge graph, offline mode, and explicit clinical-use limits.
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alphafold-sovereign-mcp更多Databases服务器
浏览完整目录安全概况
已认领和已认证的服务器每周接受一次静态扫描，显示代码能触及的范围（外部服务、环境变量、shell 命令、代理配置目录）以及带有已知公告的依赖。认领此列表即可获得。 安全概况的工作原理
30 个工具中显示 30 个
文档中列出的工具 (30)
内容来自项目文档。服务器握手不会验证每个工具的说明或行为。
analyze_structural_confidence
mean pLDDT + confidence tier + PAE-derived domain boundaries
assess_target_druggability
UniProt → HOT/WARM/COLD/NOTDRUGGABLE tier
classify_variant_acmg
HGVS → ACMG/AMP criteria checklist (PVS1, PM2, PP3, BP4, BP7, BS1, PP5)
compare_disease_target_overlap
Jaccard similarity of target sets for two diseases
compare_proteins_topologically
Pairwise L2 fingerprint-distance matrix for 2–10 proteins
compute_topology_fingerprint
64-dim TDA fingerprint (Betti numbers β₀ β₁ β₂)
detect_intrinsically_disordered
IDR map (linkers, tails, long IDRs)
export_research_dataset
Export tables to JSON for pandas/ML pipelines
find_drug_gene_network
Traverse the local drug–gene–disease graph
find_drug_repurposing_candidates
MONDO → candidates ranked by OT evidence × ChEMBL phase
find_evolutionary_structural_shifts
Cross-species structural divergence (TDA + Ensembl orthologs)
generate_variant_clinical_report
HGVS → multi-source report + draft ACMG/AMP criteria
get_common_disease_targets
Parallel profiling across curated MONDO diseases
get_disease_targets
Top drug targets for a MONDO disease (Open Targets)
get_gene_phenotype_profile
HPO phenotypes + gnomAD constraint for a gene
get_knowledge_graph_stats
Database size, entity counts, last activity
get_orphan_disease_atlas
Orphanet → MONDO → HPO + OT targets
get_protein_structure
Retrieve an AlphaFold model: metadata, download URLs, optional coordinates
get_target_diseases
Top diseases for a UniProt target (Open Targets)
lookup_disease
MONDO record + hierarchy + ICD cross-references
lookup_phenotype
HPO term + associated diseases
map_disease_drug_landscape
MONDO → approved drugs + pipeline + ChEMBL phase counts
phenotype_to_structures
HPO → diseases → OT targets → UniProt IDs
query_protein_database
Search locally stored protein assessments
query_variant_database
Search locally stored variant triage results
resolve_icd10_to_mondo
ICD-10 code → MONDO disease record
score_binding_pocket_geometry
Geometric pocket detection + heuristic druggability index
search_diseases
Full-text MONDO ontology search
synthesize_protein_dossier
UniProt → multi-source briefing
triage_variant_3d
HGVS → ClinVar + gnomAD constraint (disease/structure context: pointer notes)