Uniprot MCP
未认领Auditable UniProt MCP server with per-response SHA-256 provenance, release pinning, verification, and offline replay.
01 / 选择客户端
03 / 添加配置
claude mcp add --transport stdio 'uniprot-mcp' -- 'uvx' 'uniprot-mcp-server'04 / 在客户端中确认
打开客户端的 MCP 设置，确认服务器已连接并列出工具。复制配置不代表连接成功。
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浏览完整目录安全概况
已认领和已认证的服务器每周接受一次静态扫描，显示代码能触及的范围（外部服务、环境变量、shell 命令、代理配置目录）以及带有已知公告的依赖。认领此列表即可获得。 安全概况的工作原理
40 个工具中显示 40 个
文档中列出的工具 (40)
内容来自项目文档。服务器握手不会验证每个工具的说明或行为。
uniprot_batch_entries
Up to 100 entries in one call; invalid accessions filtered client-side.
uniprot_compute_properties
Derived sequence chemistry from the FASTA: MW / pI / GRAVY / aromaticity / charge / ε₂₈₀.
uniprot_features_at_position
Every feature overlapping a residue position. Critical for variant-effect interpretation.
uniprot_get_active_sites
Catalytic and ligand-binding residues: active sites, binding sites, sites, metal binding, DNA binding. The residue-level chemistry of the protein.
uniprot_get_alphafold_confidence
alphafold.ebi.ac.uk
uniprot_get_citation
Citation record by ID (typically a PubMed numeric ID).
uniprot_get_cross_refs
Raw cross-references to PDB, Pfam, Ensembl, Reactome, KEGG, STRING …
uniprot_get_disease_associations
Structured disease records from DISEASE-type comments: name + acronym + UniProt disease ID + OMIM cross-ref + description.
uniprot_get_entry
Full UniProt entry (e.g. P04637 for p53). Function, gene, organism, disease, cross-refs.
uniprot_get_evidence_summary
Aggregate ECO codes (Evidence and Conclusion Ontology) across an entry and grade them into a 0-100 evidence-confidence score (high / moderate / low / very-low). Distinguishes wet-lab confirmed from inferred-by-similarity from automatic.
uniprot_get_features
Domains, binding sites, PTMs, signal peptides — optional type filter.
uniprot_get_go_terms
GO annotations grouped by aspect (F / P / C).
uniprot_get_keyword
Keyword by ID (e.g. KW-0007 = Acetylation). Definition, synonyms, GO refs, hierarchy.
uniprot_get_processing_features
Maturation features: signal peptide, propeptide, transit peptide, initiator methionine, chain, peptide. Essential for therapeutic-protein engineering and pathogen-secretion analysis.
uniprot_get_proteome
Proteome by UP ID (UP000005640 = human). Counts, BUSCO score, components.
uniprot_get_ptms
Post-translational modifications: modified residues (phospho/acetyl/methyl), glycosylation, lipidation (GPI/prenyl/palmitoyl), disulfide bonds, cross-links.
uniprot_get_publications
rest.uniprot.org
uniprot_get_sequence
FASTA. PIR-style provenance comment block above the first record (BLAST+ / biopython compatible).
uniprot_get_subcellular_location
Subcellular-location term by ID (e.g. SL-0039 = Cell membrane).
uniprot_get_uniparc
Sequence-archive record by UPI (UPI000002ED67).
uniprot_get_uniref
UniRef cluster by ID (UniRef50P04637, UniRef90P04637, UniRef100P04637).
uniprot_get_variants
Natural variants and disease mutations.
uniprot_id_mapping
Map IDs between databases (GeneName → UniProtKB, PDB → UniProtKB, …).
uniprot_lookup_variant
HGVS-shorthand match (R175H, V600E, R248) against UniProt's natural-variant features.
uniprot_provenance_verify
Re-fetch a previously recorded URL and compare release tag + canonical response SHA-256. Five verdicts (verified, releasedrift, hashdrift, releaseandhashdrift, urlunreachable) each with an advice string.
uniprot_resolve_alphafold
AlphaFold model id + EBI viewer URL (model id only — for pLDDT call the dedicated tool below).
uniprot_resolve_chembl
ChEMBL drug-target id + EBI target-card URL.
uniprot_resolve_clinvar
eutils.ncbi.nlm.nih.gov
uniprot_resolve_interpro
InterPro signatures: id + entry name.
uniprot_resolve_orthology
Group orthology cross-references by source DB (KEGG / OMA / OrthoDB / eggNOG / 8 more).
uniprot_resolve_pdb
PDB structures: id + method + resolution + chain coverage.
uniprot_search
UniProt query language — gene, organism, taxon ID, reviewed flag, free text.
uniprot_search_citations
Index search across UniProt citations.
uniprot_search_keywords
Free-text keyword search.
uniprot_search_proteomes
Filter by organism / type / completeness.
uniprot_search_subcellular_locations
Free-text location search.
uniprot_search_uniparc
UniParc full-text search.
uniprot_search_uniref
Cluster search with identitytier filter (50 / 90 / 100).
uniprot_target_dossier
One-call comprehensive characterisation: nine sections — identity / function / chemistry / structure / drug-target / disease / variants / functional annotations / cross-refs.
uniprot_taxonomy_search
Search UniProt taxonomy by organism name.